ABSTRACT
Furosemide acts primarily on the thick ascending limb of the loop of Henle and inhibits the chloride transport in this site, which is the main mechanism of diuretic action of furosemide However, the precise molecular mechanism of diuretic action of furosemide is still unknown. Recent studies have shown that cGMP might be involved in diuretic effect of furosemide. In this study, the effects of furosemide on the renal tissue level of cGMP in vivo and on the renal guanylate cyclase in vitro were investigated. Also, the influence of aspirin on these effects was examined. The results were as follows: 1. The renal tissue level of cGMP was increased after administration of furosemide, but decreased after administration of aspirin. A combined administration of furosemide and aspirin increased the renal tissue level of cGMP, but the degree of elevation was less than those of the furosemide group. 2. The renal guanylate cyclase activity was slightly increased by furosemide, but this increase was not significant. The renal guanylate cyclase activity was significantly increased by arachidonic acid. Furosemide potentiated the effect of arachidonic acid on renal guanylate cyclase activity, which was inhibited by aspirin. These results indicate that effect of furosemide on renal tissue level of cGMP may be indirect effect that furosemide activates guanylate cyclase by means of increasing prostaglandin synthesis.
Subject(s)
Animals , Rats , Arachidonic Acid , Aspirin , Diuretics , Extremities , Furosemide , Guanylate Cyclase , Loop of HenleABSTRACT
The clinical observation were performed 66 cases of reoperation in department of Urology. Catholic Medical College during the period from August. 1968 to July, 1977. The result were as follows: 1. Of the total patients underwent reoperation were 66 cases (3.4%), which were operated previously from our department (36 cases) and another hospital(30 cases), respectively. 2. In organ distribution, the ureter were 22 cases(31. 9%), urethra 17 cases(24.7%) Kidney 10 cases (14.5%), bladder 10 cases(14.5%). 3. The title of reoperations consist of urethroplasty 15 cases(31. 3%), fistulectomy 13 cases(20. 3%), nephrectomy 7 cases(11. 1%), cutaneoureterostomy 6 cases(9. 4%), ureteral reimplantation 5 cases(7. 8%).
Subject(s)
Humans , Kidney , Nephrectomy , Reoperation , Replantation , Ureter , Urethra , Urinary Bladder , UrologyABSTRACT
A statistical observation was made on 856 in-patients with operative procedures in the Department of Urology, Catholic Medical College, During the period from January 1, 1971 to December 31, 1975.
Subject(s)
Surgical Procedures, Operative , UrologyABSTRACT
Spontaneous Subcapsular hematoma of the kidney is relatively uncommon. Although several cases have been recorded in the literature, the diagnosis was seldom made preoperatively. Selective renal angiography provide an excellent means of diagnosing this lesion prior to surgery. Case I: A 37 years male was admitted with the right flank pain and hematuria. Excretory urogram showed moderate hydronephrosis and a cystic shadow compressing upper calices. Selective renal angiography showed strip-like curvilinear capsular density outside the nonopacifying mass. By exploration, blood clots, about 300 c. c., between renal parenchyma and renal capsule was evacuated. The cause of the hematoma is uncertain whether it is from ruptured aneurysm or due to hydronephrosis. Case II : A 54-year-old woman was hospitalized with right flank discomfortness and mild fever. Intravenous pyelogram revealed increased size of the right kidney and angiogram demonstrated the compressed and flattened renal parenchyma by a nonopacifying mass and renal capsule on the outer margin of the mass. Blood clots, about 200 c.c., inside the renal capsule which compressed renal parenchyma was evacuated.
Subject(s)
Female , Humans , Male , Middle Aged , Aneurysm, Ruptured , Angiography , Diagnosis , Fever , Flank Pain , Hematoma , Hematuria , Hydronephrosis , KidneyABSTRACT
We have experienced an unusual case of hemorrhagic renal cyst in the rt. kidney at 58 years old woman. The Rt. kidney was enlarged, and showed a few subcapsular ischemic areas The color of kidney was dark brown. As the cyst at lower pole of rt. kidney was dissected, hemorrhagic fluid visualized in the cystic cavity. The final pathologic finding was renal cyst associated with malignant change and renal cell carcinoma at another renal parenchyma. Herein, hemorrhagic renal cyst, a rare clinical entity, was reported with review of literatures.